Age, Sex, and Depot‐Specific Differences in Adipose‐Tissue Estrogen Receptors in Individuals with Obesity
- Resource Type
- Authors
- James Pitt; Nicole Spencer; Jillian Barnas; Jill A. Kanaley; Jay W. Porter; Rebecca J. Welly; Victoria J. Vieira-Potter
- Source
- Obesity (Silver Spring)
- Subject
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Adipose tissue
Estrogen receptor
030209 endocrinology & metabolism
White adipose tissue
Article
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
medicine
Humans
Obesity
030212 general & internal medicine
Aromatase
Aged
Sex Characteristics
Nutrition and Dietetics
biology
business.industry
Age Factors
Middle Aged
medicine.disease
Thermogenin
Adipose Tissue
Receptors, Estrogen
biology.protein
Female
business
Estrogen receptor alpha
Sex characteristics
- Language
- ISSN
- 1930-739X
1930-7381
OBJECTIVE The aim of this study was to examine the effects of sex and menopausal status on depot-specific estrogen signaling in white adipose tissue (AT) in age-matched men and women with morbid obesity. METHODS A total of 28 premenopausal women, 16 postmenopausal women, and 27 age-matched men undergoing bariatric surgery were compared for omental (OM) AT (OMAT) and abdominal subcutaneous (SQ) AT (SQAT) genes and proteins. RESULTS With the exception of fasting nonesterified fatty acids being higher in women (P