Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake
- Resource Type
- Authors
- N. E. van‘t Veer; Rogier M. P. H. Crolla; Antonius A.M. Ermens; T. Mulder; M. F. Q. Kluytmans-van den Bergh; Jan Kluytmans; Jannie Romme
- Source
- Antimicrobial Agents and Chemotherapy, 62(1). American Society for Microbiology
- Subject
- Male
medicine.medical_specialty
medicine.drug_class
Antibiotics
Administration, Oral
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Pharmacotherapy
Oral administration
Internal medicine
Tobramycin
Journal Article
Medicine
Humans
Surgical Wound Infection
Pharmacology (medical)
030212 general & internal medicine
Prospective Studies
Antibiotic prophylaxis
Prospective cohort study
Aged
Pharmacology
business.industry
Colistin
030208 emergency & critical care medicine
Antibiotic Prophylaxis
Middle Aged
Colorectal surgery
Anti-Bacterial Agents
Infectious Diseases
Surgery
Female
business
Colorectal Surgery
medicine.drug
- Language
- ISSN
- 1098-6596
0066-4804
Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.