Evaluation of a sensor algorithm for motor state rating in Parkinson's disease
- Resource Type
- Authors
- Dongni Johansson; Ilias Thomas; Jack Spira; Dag Nyholm; Filip Bergquist; Alexander Medvedev; Anders Johansson; Fredrik Ohlsson; Anders Ericsson; Mevludin Memedi; Marina Senek; Jerker Westin
- Source
- Parkinsonismrelated disorders. 64
- Subject
- inorganic chemicals
0301 basic medicine
Male
medicine.medical_specialty
Treatment response
Parkinson's disease
Neurology
Index (economics)
Support Vector Machine
Motor Activity
Antiparkinson Agents
Levodopa
03 medical and health sciences
Wearable Electronic Devices
0302 clinical medicine
Physical medicine and rehabilitation
Accelerometry
medicine
Humans
Aged
Aged, 80 and over
Dose-Response Relationship, Drug
business.industry
Parkinson Disease
Middle Aged
medicine.disease
030104 developmental biology
Informatics
Female
Neurology (clinical)
State (computer science)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
- Language
- ISSN
- 1873-5126
A treatment response objective index (TRIS) was previously developed based on sensor data from pronation-supination tests. This study aimed to examine the performance of TRIS for medication effects in a new population sample with Parkinson's disease (PD) and its usefulness for constructing individual dose-response models.Twenty-five patients with PD performed a series of tasks throughout a levodopa challenge while wearing sensors. TRIS was used to determine motor changes in pronation-supination tests following a single levodopa dose, and was compared to clinical ratings including the Treatment Response Scale (TRS) and six sub-items of the UPDRS part III.As expected, correlations between TRIS and clinical ratings were lower in the new population than in the initial study. TRIS was still significantly correlated to TRS (rThe objective sensor index shows promise for constructing individual dose-response models, but further evaluations and retraining of the TRIS algorithm are desirable to improve its performance and to ensure its clinical effectiveness.