Estrogen receptors and clinical correlations with human prostatic disease
- Resource Type
- Authors
- Avery A. Sandberg; J. Edson Pontes; Gerald P. Murphy; J.P. Karr; Rashad Y. Kirdani
- Source
- Urology. 19:399-403
- Subject
- Male
medicine.medical_specialty
Pathology
Urology
Prostatic Hyperplasia
Estrogen receptor
Adenocarcinoma
urologic and male genital diseases
High-performance liquid chromatography
Cytosol
Internal medicine
medicine
Humans
Estrogen binding
Receptor
Chromatography, High Pressure Liquid
Binding Sites
business.industry
Prostatic Neoplasms
Cancer
Hyperplasia
medicine.disease
Endocrinology
Receptors, Estrogen
business
- Language
- ISSN
- 0090-4295
Measurement of estrogen binding in human prostate using high-pressure liquid chromatography (HPLC) revealed the presence of cytosolic estrogen receptors (ER) both in benign prostatic hyperplasia (BPH) and adenocarcinoma. Receptor concentrations correlated with several histopathologic features in the specimens analyzed. Estrogen receptor levels generally were higher in BPH than in cancer specimens although there was a subgroup of patients with poorly differentiated carcinoma with levels higher than those of BPH. HPLC can be used for measuring ER in 50 μl. of cytosol, and thus needle biopsy specimens will be analyzed routinely for ER with this micromethod.