Cytokine Induced Killer (CIK) cells for the treatment of haematological neoplasms
- Resource Type
- Authors
- J. Golay; Martino Introna; Alessandro Rambaldi
- Source
- Immunology letters. 155(1-2)
- Subject
- Cytotoxicity, Immunologic
medicine.medical_treatment
Immunology
Population
Cell
Biology
CD8-Positive T-Lymphocytes
medicine
Immunology and Allergy
Cytotoxic T cell
Animals
Humans
Cytotoxicity
education
Killer Cells, Lymphokine-Activated
education.field_of_study
Clinical Trials as Topic
Hematopoietic Stem Cell Transplantation
Natural killer T cell
In vitro
CD56 Antigen
Killer Cells, Natural
Cytokine
medicine.anatomical_structure
Hematologic Neoplasms
Cytokines
Immunotherapy
Homing (hematopoietic)
- Language
- ISSN
- 1879-0542
Cytokine Induced Killer (CIK) cells are in vitro activated human CD8 T cells which have maintained several characteristics of T-EMRA cells and additionally acquired non specific anti tumoral cytotoxicity and CD56 overexpression, thus representing a cell population with double T and NK phenotype. Due to their in vivo intratumoral homing and lack of Graft versus Host (GVH) reactivity, CIK cells have been extensively used in cancer patients either in autologous or allogeneic contexts. Here we summarise CIK main biological features as well as their most prominent clinical results.