Corrigendum to 'Long-term valproic acid exposure increases the number of neocortical neurons in the developing rat brain' [Neurosci. Lett. 580 (2014) 12–16]
- Resource Type
- Authors
- Arne Møller; Freja Bertelsen; Jørgen Scheel-Krüger; Jens R. Nyengaard; Anne Sabers
- Source
- Neuroscience Letters. 588:203-207
- Subject
- medicine.medical_specialty
Valproic Acid
Fetus
Pregnancy
Neocortex
business.industry
General Neuroscience
Rat brain
medicine.disease
medicine.anatomical_structure
Animal model
Endocrinology
Lactation
Internal medicine
medicine
Autism
lipids (amino acids, peptides, and proteins)
business
medicine.drug
- Language
- ISSN
- 0304-3940
The aim of this study was to test the hypothesis that long-term fetal valproic acid (VPA) exposure at doses relevant to the human clinic interferes with normal brain development. Pregnant rats were given intraperitoneal injections of VPA (20 mg/kg or 100 mg/kg) continuously during the last 9–12 days of pregnancy and during the lactation period until sacrifice on the 23rd postnatal day. Total number of neocortical neurons was estimated using the optical fractionator and frontal cortical thicknesses were sampled in VPA exposed pups compared with an unexposed control group. We found that pups exposed to 20 mg/kg and 100 mg/kg doses of VPA had statistically significant higher total number of neurons in neocortex by 15.8% and 12.3%, respectively, ( p 6 neocortical neurons ( p p