Procalcitonin and C-Reactive Protein in Umbilical Cord Blood as Markers for Early Suspicion of Infection in Newborns of Women with Prenatal Urinary Tract Infection
- Resource Type
- Authors
- Adauto Dutra; Rafael Del Castilho Villalba; Adriana Cersósimo; Israel Figueiredo Junior; Moraes Barbosa
- Source
- IOSR Journal of Dental and Medical Sciences. 15:37-39
- Subject
- Asphyxia
medicine.medical_specialty
Pregnancy
biology
Obstetrics
business.industry
Urinary system
C-reactive protein
bacterial infections and mycoses
medicine.disease
Umbilical cord
Procalcitonin
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
030225 pediatrics
Relative risk
Immunology
medicine
biology.protein
030212 general & internal medicine
medicine.symptom
business
Prospective cohort study
- Language
- ISSN
- 2279-0853
2279-0861
Objective: to investigate whether concentrations of procalcitonin (PCT) and C-reactive protein (CRP) in the umbilical cord blood (UCB) are valid biomarkers for the detection of infection in newborns of pregnant women with urinary tract infection (UTI). Methods: PCT and CRP were measured from UCB and were verified through a prospective study of newborns with appropriate birth weights, without asphyxia or signs of bacterial infection whose mothers were diagnosed with untreated or inadequately treated UTI during the final trimester of pregnancy. The blood of newborns was analyzed according to Rodwell criteria. Was calculated the relative risk to detect altered PCT and/or CRP concentration in UCB in newborn with positive Rodwell criteria. Results: samples from 97 newborns at term were analyzed according to Rodwell criteria. Fifty-six of them showed negative criteria. The RR was 2.0 (95% CI – 1.1 – 3.6 p = 0.03) according to PCT and 2.3 (95% CI – 1.1- 4.9) p = 0.03 according to CRP. Conclusion: A normal value to PCT or CRP available from UCB duplicate the possibility to Rodwell negative criteria result in peripheral blood of the neonate, away from the possibility of infection in newborn infants of mothers who had UTI in the pregnancy.