Degradable and colloidally stable zwitterionic-functionalized silica nanoparticles
- Resource Type
- Authors
- Mateus Borba Cardoso; Iris Renata Sousa Ribeiro; Jefferson Bettini; Flávia Elisa Galdino; Andressa da Cruz Schneid
- Source
- Nanomedicine (London, England). 16(2)
- Subject
- Biocompatibility
Chemistry
Biomedical Engineering
Medicine (miscellaneous)
Nanoparticle
Bioengineering
02 engineering and technology
Development
Mesoporous silica
Silanes
010402 general chemistry
021001 nanoscience & nanotechnology
Silicon Dioxide
01 natural sciences
Silane
0104 chemical sciences
Colloid
chemistry.chemical_compound
Chemical engineering
Moiety
Particle
Degradation (geology)
Nanoparticles
General Materials Science
0210 nano-technology
- Language
- ISSN
- 1748-6963
Aim: This work is focused on obtaining degradable mesoporous silica nanoparticles (DMSNs) which are able to maintain their colloidal stability in complex biological media. Materials & methods: DMSNs were synthesized using different ratios of disulfide organosilane (degradable structural moiety) and further functionalized with sulfobetaine silane (SBS) to enhance colloidal stability and improve biological compatibility. Results: There was a clear trade-off between nanoparticle degradability and colloidal stability, since full optimization of the degradation process generated unstable particles, while enhancing colloidal stability resulted in poor DMSNs degradation. It was also shown that acidic pH improved particle degradation which is commonly triggered by reduction stimulus. Conclusion: A chemical composition window was found where DMSNs presented satisfactory colloidal stability in biologically relevant medium, meaningful degradation profiles and high biocompatibility.