Effect of glutathione liposomes on diabetic nephropathy based on oxidative stress and polyol pathway mechanism
- Resource Type
- Authors
- Huajuan Shen; Wei Wang
- Source
- Journal of Liposome Research. 31:317-325
- Subject
- Antioxidant
Polymers
medicine.medical_treatment
Pharmaceutical Science
02 engineering and technology
Pharmacology
medicine.disease_cause
030226 pharmacology & pharmacy
Antioxidants
Diabetic nephropathy
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Polyol pathway
stomatognathic system
Diabetes Mellitus
medicine
Humans
Diabetic Nephropathies
Liposome
Mechanism (biology)
Glutathione
021001 nanoscience & nanotechnology
medicine.disease
Bioavailability
Oxidative Stress
stomatognathic diseases
chemistry
Liposomes
0210 nano-technology
Oxidative stress
- Language
- ISSN
- 1532-2394
0898-2104
A novel antioxidant glutathione liposomes (GSH-LIP) were prepared and applied for diabetic nephropathy therapy. GSH-LIP not only improve the bioavailability and antioxidant capacity of glutathione to scavenge redundant ROS inducing by oxidative stress, but also effectively inhibit the activity of AR and sorbitol accumulation in polyol pathway. The imaging in vivo showed that GSH-LIP could target kidney and significantly improve renal pathology. GSH-LIP may become a new AR inhibitor and antioxidant, which provides a new theoretical basis for the study of drugs for therapy diabetic nephropathy.