BACKGROUND Telerehabilitation serving as a specific form of Digital Therapy, draws much attention for individuals with low back pain (LBP) in recent years. To facilitate the accessibility of medical care, telerehabilitation has been reported to have positive role in improving the symptoms of LBP patients through online exercise guiding, medicine uptake, cognitive behavior treatment, and feedback from wearable devices. OBJECTIVE To conduct a systematic review to investigate the feasibility, safety and efficacy of telerehabilitation for individuals with low back pain. METHODS The database of PubMed, Ovid, Embase and Web of Science were searched from inception through June 20,2021.Randomized controlled trials were chosen for data analysis with the main outcomes and measures being pain intensity, disability and function. RESULTS Of 3190 articles searched, 12 studies from 6 countries were included and 5 studies were in the meta-analysis. The result showed telerehabilitation could be effective for LBP on reduction of pain intensity (SMD = -0.40; 95% CI= [-0.80,0.00], P =0.05) and improvement of disability (SMD = -0.17; 95% CI= [-0.46,0.12], P =0.24) and function (SMD = 0.42; 95% CI= [0.01, 0.83], P =0.04). Telerehabilitation did not provide superiority of outcome when compared to the usual rehabilitation. Only 2 studies reported adverse events that were identified not from the remote intervention. Telerehabilitation via internet-based models or services showed a promising effect on the reduction of opioid use and improvement of rehabilitative education for the LBP individuals. CONCLUSIONS In this systematic review, telerehabilitation has been proved to be effective for the individuals with LBP in the community setting or at home. No adverse events related to remote intervention have been reported. The current evidence is not sufficient to support the superiority of telerehabilitation for LBP when compared to the usual rehabilitation. Robust clinical trials are needed to explore the optimal telerehabilitation care with internet-based models or services to promote the symptoms of LBP patients.