Background Assessment of disease activity status in vitiligo patients is of great importance for disease management. Clinically visible signs such as confetti-like depigmentation, Koebner's phenomenon and hypochromic areas/borders have previously been associated with disease activity in a systematic review. Strong evidence of an association was found for Koebner's phenomenon. However, for the other two signs, more data from studies with standardized scoring systems are needed to confirm their value (1). In recent years, the Vitiligo Signs of Activity Score (VSAS) and the Vitiligo Disease Activity Score (VDAS) were developed and validated to standardize the assessment of clinical signs and disease evolution (worsening) in vitiligo patients, respectively (2,3). These scoring systems could support research on the clinical signs in vitiligo and unravel their true predictive value. Objectives This study evaluates the value of confetti-like depigmentation, Koebner's phenomenon and hypochromic areas in predicting disease activity in vitiligo patients. Methods A cross-sectional, observational study was conducted at Ghent University Hospital in 315 vitiligo patients (non-segmental). VSAS was used to score the presence of the three visible clinical signs. The VDAS was used to evaluate disease progression (worsening) over the previous 3 – 12 months. Results (preliminary results) At least one clinical sign was observed in 43.1% of the study population. Confetti-like depigmentation, Koebner’s phenomenon and hypochromic areas/borders were significantly correlated with vitiligo progression over the past 3 to 12 months (p