GDP Release from the Open Conformation of Gα Requires Allosteric Signaling from the Agonist-Bound Human β
- Resource Type
- Authors
- Vikash, Kumar; Hannah, Hoag; Safaa, Sader; Nicolas, Scorese; Haiguang, Liu; Chun, Wu
- Source
- Journal of chemical information and modeling. 60(8)
- Subject
- GTP-Binding Proteins
Protein Conformation
Humans
Receptors, Adrenergic, beta-2
Ligands
Guanosine Diphosphate
Protein Binding
Receptors, G-Protein-Coupled
Signal Transduction
- Language
- ISSN
- 1549-960X
G-protein-coupled receptors (GPCRs) transmit signals into the cell in response to ligand binding at its extracellular domain, which is characterized by the coupling of agonist-induced receptor conformational change to guanine nucleotide (GDP) exchange with guanosine triphosphate on a heterotrimeric (αβγ) guanine nucleotide-binding protein (G-protein), leading to the activation of the G-protein. The signal transduction mechanisms have been widely researched