Staphylococcus aureus patogeniškumo veiksnių įtakos vaikų infekcijų eigai įvertinimas
- Resource Type
- Authors
- Petraitienė, Birutė
- Source
- Subject
- S. aureus
PVL
Panton-Valentine leukocidin
mecA
MRSA
bacteria
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
- Language
- Lithuanian
The relevance of the subject. S. aureus-PVL(+) is the most common cause of skin and soft tissue infections, but in case of invasive S. aureus-PVL(+) infections clinical manifestation is more severe. Data regarding the prevalence of PVL toxin among S. aureus infection in Lithuania are lacking. The association of the mecA and resistance to methicillin and some beta-lactams of S. aureus pathogen is well known. Data regarding the effect on demographic and clinical characteristics by S. aureus containing the mecA are lacking. The aim of the study. To evaluate the influence of pvl and mecA pathogenicity factors on the clinical course of the S. aureus induced infections in children. The objectives. 1. To investigate the prevalence of S. aureus-PVL(+) and MRSA-PVL(+) in children admitted and treated at Kauno klinikos. 2. To evaluate the relationship of S. aureus-PVL(+) with demographic data, laboratory findings, clinical conditions and outcomes of associated conditions. 3. To identify predictors of the S. aureus-PVL(+) infection at the onset of the disease and to define the factors associated with severe course of the disease. 4. To evaluate the methods of treatment of S. aureus infection. 5. To evaluate the antimicrobial resistance of S. aureus and the prevalence among community-acquired and hospital-acquired infections. 6. To investigate the prevalence of the mecA and to determine its link to MRSA and the associations in respect to demographic parameters and clinical conditions.