Cross-coupled pairs are certainly among the most widely adopted fundamental circuits still in use today. This elegant device arrangement yields broadband positive feedback with high gain and low power, desirable features both in analog and digital applications [1]. Its small signal properties are consistently leveraged in oscillators, impedance negators and to boost gain of transconductors, while the bistable behavior is exploited in static latches and memory cells. Traditionally, the regeneration capability is leveraged in the design of sense amplifiers and high-speed comparators. In this work, we investigated the performance of the cross-coupled pair for discrete-time linear amplification and we show that its regeneration feature proves to be attractive for implementing Programmable-Gain Amplifiers (PGAs).