Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold?
- Resource Type
- Authors
- Andrew R. Pettitt; Gillian G. Johnson; Daniel F. Carr; Munir Pirmohamed
- Source
- PHARMACOGENOMICS
- Subject
- Pharmacology
Bendamustine
Cyclophosphamide
business.industry
Chronic lymphocytic leukemia
Clone (cell biology)
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Fludarabine
Leukemia
Pharmacogenetics
Pharmacogenomics
Immunology
Genetics
medicine
Humans
Molecular Medicine
business
medicine.drug
- Language
- English
…there is accumulating evidence that treatment outcome in chronic lymphocytic leukemia can be influenced by germline polymorphisms that affect drug disposition and/or pharmacodynamics, and that these effects may explain some of the variability in treatment outcome that cannot be explained by genotypic and phenotypic variation of the malignant clone.