Table S1. Characteristics of all enrolled patients (HCC=35, CRC=16), not previous treated with chemotherapy Table S2. List of all antibodies for FC analysis Figure S1: CD4 and CD8 T cells expressed high levels of PD1 in TUM district and showed mostly an effector memory phenotype in CRC Figure S2: Distribution of Wnt3a in serum, NTUM- or TUM-derived CM, and expression of Wnt3a/β-catenin axis in NTUM and TUM-infiltrating CD4 and CD8 T cells from CRC patients Figure S3: Analysis of Frizzled receptor 1 expression among CD4 and CD8 T cells in periphery, nontumor and tumor samples of HCC patients Figure S4: β-catenin+ tumor-infiltrating CD4 T cells in presence of anti-Wnt3a do not down-regulated TNF-α prduction