Objective To evaluate usability of and satisfaction with OrCam MyEye, a finger-size wearable assistive technology device for visually impaired during real-world tasks. Methods This prospective multicenter study was conducted on visually impaired people recruited from 5 vision rehabilitation centers. Patients performed real-world tasks such as near and distance reading, money handling, colour identification and faces recognition in 2 different scenarios: without using any low vision aid and with OrCam. System Usability Scale (SUS), Patient’s Global Impression of Change (PGIC), the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) and the Psychosocial Impact of Assistive Devices Scale (PIADS) were administered after the use of the OrCam device. Results Among the 100 participants, use of OrCam MyEye device improved many daily-living tasks (F = 1.67, P 2 = 0.72, P