Amyloid burden identifies neuropsychological phenotypes at increased risk of progression to Alzheimer's disease in mild cognitive impairment patients
- Resource Type
- Authors
- Elena Carabelli; Antonio Tartaglione; Mattia Riondato; Antonio Mannironi; Luigi Mansi; Chiara Passera; Marina De Biasi; Giampiero Giovacchini; Franca Foppiano; Bruno Alfano; Andrea Ciarmiello; Elisabetta Giovannini; O. Ferrando
- Source
- European Journal of Nuclear Medicine and Molecular Imaging
- Subject
- Oncology
Male
Risk
medicine.medical_specialty
Amyloid
PET imaging
Disease
Neuropsychological Tests
Beta-amyloid
Cognitive trajectory
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Memory
Internal medicine
Positive predicative value
mental disorders
medicine
Memory impairment
Humans
Radiology, Nuclear Medicine and imaging
Cognitive Dysfunction
10. No inequality
Prospective cohort study
Episodic memory
Aged
business.industry
Neuropsychology
Mild cognitive impairment
Cognition
General Medicine
Middle Aged
3. Good health
Cross-Sectional Studies
Phenotype
Memory performance
030220 oncology & carcinogenesis
Disease Progression
Female
Original Article
business
- Language
- ISSN
- 1619-7089
Purpose The extent of amyloid burden associated with cognitive impairment in amnestic mild cognitive impairment is unknown. The primary aim of the study was to determine the extent to which amyloid burden is associated to the cognitive impairment. The secondary objective was to test the relationship between amyloid accumulation and memory or cognitive impairment. Materials and methods In this prospective study 66 participants with amnestic mild cognitive impairment underwent clinical, neuropsychological and PET amyloid imaging tests. Composite scores assessing memory and non-memory domains were used to identify two clinical classes of neuropsychological phenotypes expressing different degree of cognitive impairment. Detection of amyloid status and definition of optimal amyloid ± cutoff for discrimination relied on unsupervised k-means clustering method. Results Threshold for identifying low and high amyloid retention groups was of SUVr = 1.3. Aß + participants showed poorer global cognitive and episodic memory performance than subjects with low amyloid deposition. Aß positivity significantly identified individuals with episodic memory impairment with a sensitivity and specificity of 80 and 79%, (χ2 = 21.48; P