Phytochemical investigation of different plant parts of Schiekia orinocensis , a neotropical member of the Haemodoraceae, resulted in the structure elucidation of thirteen phenylphenalenone-type compounds, five known flavonoids and one new 1,3-disubstituted glycerol derivative. Six of the phenylphenalenones are reported for the first time, among them five minor compounds derived from the reaction with acetone used for extraction. The occurrence of the phenylphenalenones possessing C 19 , C 18 O or C 18 N skeletons confirmed the chemotaxonomic relationship of S. orinocensis with other members of the Haemodoraceae, especially the Haemodoroideae subfamily. The tissue-specific occurrence of the identified compounds was also subject to this study.