Through machining superalloy GH4169 in center lathe by four kinds material of tool, which are YT763, K313, KC5510 and SM1105, analyzing the changings of cutting force and surface roughness in different material of tool and the forms of tool wear. As the experiment data shows, there is little influence of the different tool in material with the same coating to cutting force and surface roughness. KC5510 is more suitable for constant speed cutting GH4169, which offers the choices of tool material when machining superalloy in common speed.