Anatomical human fitting of the BiVACOR total artificial heart
- Resource Type
- Authors
- Mark Connellan; Christina Kure; A. Watson; Paul Jansz; Christopher S. Hayward; David C. McGiffin; Daniel Timms; Arjun Iyer; Sam Emmanuel; Emily Granger
- Source
- Artificial Organs. 46:50-56
- Subject
- Adult
Male
medicine.medical_treatment
Biomedical Engineering
Pulsatile flow
Medicine (miscellaneous)
Bioengineering
Heart, Artificial
law.invention
Biomaterials
law
medicine.artery
Artificial heart
Humans
Medicine
Aged
Heart Failure
Heart transplantation
Aorta
Ischemic cardiomyopathy
business.industry
Heart
General Medicine
Middle Aged
Thorax
medicine.disease
medicine.anatomical_structure
Heart failure
Pulmonary artery
Thoracic vertebrae
Heart Transplantation
Female
Tomography, X-Ray Computed
business
Nuclear medicine
- Language
- ISSN
- 1525-1594
0160-564X
Background BiVACOR is a novel total artificial heart (TAH) utilizing a single centrifugal magnetically levitated rotor with the ability to modulate pulsatile flow. The device has been successfully tested in a bovine model. We undertook a multicenter anatomical and virtual fitting study of the BiVACOR in patients undergoing heart transplantation. Methods 10 patients were recruited across two heart transplant centers. A sterilized 1:1 titanium model of the device was inserted into the patient's chest post heart explant, prior to implantation of the donor heart. Measurements were recorded in situ. The device was then removed. Following this, retrospective 3D reconstructions were created from computed tomography chest scans to simulate a virtual fitting. Results Mean age was 53 years (range 38-67). Mean BMI was 28 (range 20-37). Heart failure etiology was varied-with ischemic cardiomyopathy being the most common. Mean spine-to-sternum distance at the tenth thoracic vertebrae (T10) was 14 cm (range 11-18). Mean aorta to aortic Port distance was 0.2 cm (range 0-0.5). Mean pulmonary artery to pulmonary artery port distance was 4.2 cm (range 1-7). The device fitted suitably in all patients without gross distortion to the geometry between native vessel/chamber and port. Conclusions This study described the anatomical and virtual fitting of the BiVACOR TAH. The device fit well within the chest cavities of all 10 patients, who represented a variety of body morphologies and heart failure etiology.