Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms
- Resource Type
- Authors
- Işıl Ozer; Gülhan Sözen; Kutluhan Yılmaz; Elif Yüksel Karatoprak
- Source
- Neurological Sciences. 41:631-636
- Subject
- Male
medicine.medical_specialty
Neurology
Neurological examination
Dermatology
Electroencephalography
Polymorphism, Single Nucleotide
Asymptomatic
Gastroenterology
03 medical and health sciences
Epilepsy
Folic Acid
0302 clinical medicine
Internal medicine
medicine
Humans
Ictal
030212 general & internal medicine
Vitamin B12
Polymorphism
Child
Homocysteine
Children
Methylenetetrahydrofolate Reductase (NADPH2)
biology
medicine.diagnostic_test
business.industry
Infant
General Medicine
medicine.disease
digestive system diseases
Vitamin B 12
Psychiatry and Mental health
Child, Preschool
Methylenetetrahydrofolate reductase
MTHFR
biology.protein
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
- Language
- ISSN
- 1590-3478
1590-1874
WOS: 000519371600017 PubMed: 31734877 Objective Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism. MTHFR C677T and A1298C polymorphisms are best-defined variants of MTHFR that were reported to be associated with epilepsy development. The aim of the study was to determine the incidence of interictal epileptiform discharges on electroencephalography (EEG) in asymptomatic children with C677T and A1298C polymorphisms who had no history of seizure. Methods Children with MTHFR C677T or A1298C polymorphisms who had normal neurological examination without a history of seizure were included in the study. Blood samples for serum folate, vitamin B12, and homocysteine levels were analyzed. Sleep and awake electroencephalograms (EEG) were recorded. Results A total of 102 children (50 girls and 52 boys) with a mean age of 59.4 +/- 58.7 months were included in the study. Interictal epileptiform EEG discharges were detected in 3 children (2.9%). Conclusion There was no increase in the prevalence of interictal epileptiform discharges in seizure-free and asymptomatic children with MTHFR C677T and A1298C polymorphisms.