Additional file 6 of PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells
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- Liotti, Federica; Kumar, Narender; Prevete, Nella; Marotta, Maria; Sorriento, Daniela; Ieranò, Caterina; Ronchi, Andrea; Marino, Federica Zito; Moretti, Sonia; Colella, Renato; Efiso Puxeddu; Paladino, Simona; Kano, Yoshihito; Ohh, Michael; Scala, Stefania; Melillo, Rosa Marina
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Additional file 6: Supplementary Figure 5. Immunohistochemical evaluation of 8505c xenografts. A. Proliferation index (Ki-67) assessed by immunohistochemistry of 8505c pCMV3 and pCMV3 PD-1 cl13 xenografts harvested 28 days post-inoculation. Representative images are shown. B. Proliferation index (Ki-67) assessed by immunohistochemistry of 8505c xenografts harvested 35 days post-inoculation in mice treated with Nivolumab or control IgG4. Representative images are shown.