Bioimpedance phase angle (PA) is an index of cellular health and function, and a high PA suggest better cellular membrane integrity and a higher cell mass. PA has been identified as a valuable measurement for the diagnosis, monitoring and prognosis of various disorders. We evaluated baseline differences and change in PA in patients who attended a five months Interdisciplinary Care and Diabetes Self-management Education Program in a public primary care specialized diabetes clinic in Mexico City/Iztapalapa in 2018. In 327 persons with type 2 diabetes, PA was evaluated by bioelectrical impedance multifrequency analysis (Seca® 515/514, 50 Hz). Diabetes-related microvascular complications (MiVC) were defined by fundoscopy with mydriatic camera assessed by an ophthalmologist (retinopathy) and increased urine albumin/creatinine ratio and/or decreased estimated glomerular filtration rate (diabetic kidney disease). Women represented 67% and 56% had elementary or less education. Mean age was 55±10 years old, mean duration of diabetes was 12±8 years, 32.7% presented nephropathy and 24.8% retinopathy. Baseline PA was different among participants with or without MiVC (4.66±0.65 vs. 5.02±0.58, p Disclosure R. Silva-Tinoco: Speaker's Bureau; Self; Novo Nordisk Inc. T. Cuatecontzi-Xochitiotzi: None. L. Castillo-Martínez: None. P. León-García: None. D. Cabrera-Gerardo: None. J. Hernández: None. A. Ferreira-Hermosillo: Speaker's Bureau; Self; Sanofi, Takeda Mexico. C. Zárate: None. V.A. DeLaTorre-Saldaña: None.