The Ionic Liquid Ethyltri-n-butylphosphonium Tosylate as Solvent for the Acid-Catalyzed Hetero-Michael Reaction
- Resource Type
- Authors
- Petra Ludley; Nazira Karodia; Grace Stevenson; Dimitrios Pletsas; Xihan Liu
- Source
- ChemInform. 38
- Subject
- Reaction conditions
Addition reaction
Organic Chemistry
General Medicine
Biochemistry
Catalysis
Solvent
chemistry.chemical_compound
chemistry
Acid catalyzed
Drug Discovery
Methyl vinyl ketone
Ionic liquid
Polymer chemistry
Michael reaction
Organic chemistry
Lewis acids and bases
- Language
- ISSN
- 1522-2667
0931-7597
A new and convenient method for the acid-catalysed Michael addition reactions of alcohols, thiols and amines to methyl vinyl ketone has been developed using the ionic liquid ethyltri-n-butylphosphonium tosylate. The reaction conditions are mild and obviate the need for toxic and expensive Lewis acid catalysts, offering advantages over more commonly used systems.