LDL-C augments whereas HDL-C prevents inflammatory innate immune memory
- Resource Type
- Authors
- Yahya Sohrabi; Dennis Schwarz; Holger Reinecke
- Source
- Trends in Molecular Medicine. 28:1-4
- Subject
- medicine.medical_specialty
Inflammation
chemistry.chemical_compound
Internal medicine
medicine
Humans
Molecular Biology
Lipoprotein cholesterol
Innate immune system
business.industry
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Cardiometabolic disease
Immunity, Innate
Residual risk
medicine.anatomical_structure
Endocrinology
chemistry
Molecular Medicine
lipids (amino acids, peptides, and proteins)
Bone marrow
medicine.symptom
business
Immunologic Memory
- Language
- ISSN
- 1471-4914
Recent studies emphasize the importance of low-density lipoprotein cholesterol (LDL-C) in altering the hematopoietic cell compartment of bone marrow and of high-density lipoprotein cholesterol (HDL-C) in inhibiting metabolic endotoxemia-induced inflammation. The data suggest that these lipoproteins may exert their inflammatory or anti-inflammatory roles by modulating innate immune memory. Targeting specific LDL-C and HDL-C subfractions could therefore potentially reduce the residual risk in hepatic and cardiometabolic disease.