During the last century life expectancy of the women gets longer in the developedcountries. This is resulted in increase of postmenopausal women population. In themenopausal period, because of the estrogen deficiency, low genitourinary system getsatrophy functional disorders like dysurea, nocturea, urgency, urinary incontinence andrecurrent urinary tract infection occurs. These symptoms might prevented by hormonereplacement therapy. It is supported that urinary incontinance is associated withmenopause, however, no direct causative relationship between estrogen deficiency andurinary incontinence determined.In the menopausal period, ovarian failure, psychosomatic disorders and tissue agingare occured and which of these cause urinary incontinence is not known. As urinaryincontinence prevalance is increasing after the fifth year of menopause, incontinence maybe because of body aging. According to the controlled randomised studies, estrogen aloneor with progestrerone does not improve urinary symptoms.The objective of this study is to evaluate the effect of hormone replacement therapyon urinary incontinence in postmenopausal women. It is performed between 1 September2004 and 31 August 2005 in Cukurova University, Faculty of Medicine, Obstetrics andGynecology Department, Menopause Unit 124 postmenopausal women who had urinaryincontinence were included into the study. The patients were randomised to four groups. Ingroup 1 patients had estrogen alone or hormone replacement therapy. In group2 ptients hadtrospiyum chlorid, in group three tolderodine and in group 4 only local estrogen. Follow upwas done each 3 months for 1 year. During the followups subjective parameters wereevaluated. In this prospective cross-sectional cohort study face to face questionnaire wasused.According to our study, in the patients who took only hormone replacement therapyonly subjective improving were observed. Among all the groups, the patients who tooktolderodine symptoms were significiantly improved. 82