Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage
- Resource Type
- Authors
- Miao Wang; Chao Zhou; Lu Yu; Delian Kong; Weijing Ma; Bingchen Lv; Yan Wang; Weifeng Wu; Mingyue Zhou; Guiyun Cui
- Source
- Cellular and molecular life sciences : CMLS. 79(7)
- Subject
- Pharmacology
Neurons
Acetylation
Apoptosis
Cell Biology
Histone Deacetylase 6
Up-Regulation
Cellular and Molecular Neuroscience
Mice
Oxidative Stress
Brain Injuries
Molecular Medicine
Animals
Molecular Biology
Cerebral Hemorrhage
- Language
- ISSN
- 1420-9071
Oxidative stress impairs functional recovery after intracerebral hemorrhage (ICH). Histone deacetylase 6 (HDAC6) plays an important role in the initiation of oxidative stress. However, the function of HDAC6 in ICH and the underlying mechanism of action remain elusive. We demonstrated here that HDAC6 knockout mice were resistant to oxidative stress following ICH, as assessed by the MDA and NADPH/NADP