Additional file 1: Figure S1. CV outcomes by metformin use at baseline (unadjusted analysis). Figure S2. CV outcomes by metformin use at baseline censored for initiation and discontinuation of metformin. Figure S3. CV outcomes by metformin use at baseline adjusted for time-dependent metformin use during trial (yes/no). Figure S4. CV outcomes and all-cause mortality with semaglutide* vs placebo by baseline metformin use (SUSTAIN 6). Figure S5. CV outcomes and all-cause mortality with semaglutide* vs placebo by baseline metformin use (PIONEER 6). Figure S6. CV outcomes and mortality by baseline metformin use using inverse probability weighting.