Effect of Photoperiod and Lethal Yellow Mutation on Depression-Like Behavior and Expression of Proinflammatory Cytokines in the Hypothalamus in Mice
- Resource Type
- Authors
- D V Fursenko; E. Yu. Bazhenova; Nikita V. Khotskin; Ivan Sorokin; Alexander V. Kulikov; E. A. Kulikova
- Source
- Bulletin of Experimental Biology and Medicine. 167:100-103
- Subject
- Male
0301 basic medicine
endocrine system
medicine.medical_specialty
Photoperiod
Hypothalamus
Biology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Proinflammatory cytokine
Mice
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Gene
Swimming
photoperiodism
Depressive Disorder
Mutation
Depression
General Medicine
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
Darkness
Cytokines
Tumor necrosis factor alpha
Locomotion
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
Behavioural despair test
- Language
- ISSN
- 1573-8221
0007-4888
We studied the influence of obesity caused by lethal yellow (AY) mutation in the agouti gene, short photoperiod (4/20 h light/darkness), and combination of these factors on depressive-like behavior in the forced swimming test and expression of genes encoding proinflammatory cytokines in the hypothalamus of heterozygous male C57Bl/6-AY/a mice and their wild-type littermate controls (C57Bl/6-a/a). It was shown that AY mutation as well as short photoperiod increased depressive-like behavior in mice. No effect of the interaction of AY mutation and photoperiod on immobility in the forced swimming test was revealed. In wild-type mice, increased depressive-like behavior caused by short photoperiod was accompanied by enhanced expression of Tnf gene. Exposure to short daylight increased the expression of Nos2.