Aberrant DNA Methylation of Genomic Regions Translocated in Myeloid Malignancies
- Resource Type
- Authors
- Joan Etzell; Craig E. Litz
- Source
- Leukemia & Lymphoma. 30:1-9
- Subject
- Recombination, Genetic
Acute promyelocytic leukemia
Genetics
Cancer Research
Myeloid
Genome, Human
Mechanism (biology)
Myeloid leukemia
Chromosomal translocation
Hematology
DNA Methylation
Biology
medicine.disease
Translocation, Genetic
Germ Cells
medicine.anatomical_structure
Leukemia, Promyelocytic, Acute
Oncology
Leukemia, Myeloid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
hemic and lymphatic diseases
medicine
Humans
Aberrant DNA Methylation
- Language
- ISSN
- 1029-2403
1042-8194
The mechanism of aberrant genetic recombinatorial events in neoplasia is vaguely understood. One hypothesis is that aberrant DNA methylation may in some way predispose genomic regions to recombination. Using the t(9;22) of chronic myeloid leukemia (CML) and the t(15;17) of acute promyelocytic leukemia (APL) as models, our laboratory and others have gathered data supporting this hypothesis. These data are reviewed.