Towards a magnetic microarray for sensitive diagnostics
- Resource Type
- Authors
- Chris D. Webb; Shan X. Wang; Robert L. White; Shouheng Sun; Guanxiong Li; Seung-Young Bae; Jennifer T. Kemp
- Source
- Journal of Magnetism and Magnetic Materials. 293:731-736
- Subject
- chemistry.chemical_classification
Physics
Magnetic moment
Biomolecule
Detector
Spin valve
Giant magnetoresistance
Condensed Matter Physics
Electronic, Optical and Magnetic Materials
Tunnel magnetoresistance
Nuclear magnetic resonance
chemistry
Tunnel junction
Magnetic nanoparticles
- Language
- ISSN
- 0304-8853
We present proof-of-concept experiments and modeling towards a high-sensitivity magnetic microarray which “tags” a DNA fragment (or other biological samples) with a high-moment magnetic nanoparticle (NanoTag), which is in turn detected by a high-sensitivity spin valve (SV) or magnetic tunnel junction (MTJ) detector array. The detector can count the number of magnetic tags with a resolution of 1–20 magnetic NanoTags, potentially counting individual biomolecules.