Objectives Studies have described the experiences of racial microaggressions in everyday life and on college campuses, yet prior research has not explored how microaggressions and microaffirmations are experienced by students who are first in their family to attend college. Method This qualitative investigation of 296 open-ended survey responses described the lived experiences of first-generation college students at a large, public, predominately White institution. Results Students experienced microaggressions in the form microinsults, microassaults, and microinvalidations, and microaffirmations in the form of microsupports, microcompliments, and microvalidations on campus. Conclusions Study implications include the development and implementation of regular positive and intentional communications by faculty, staff, and peers on college campuses. (PsycINFO Database Record (c) 2019 APA, all rights reserved).