Tropical cyclone (TC) can pump heat downward through inducing intense vertical mixing. Many efforts have been made to estimate the magnitude of TC-induced ocean heat uptake (OHU), but the spatiotemporal variability of TC-induced OHU remains unclear. This study uses satellite-observed sea surface temperature (SST), subsurface temperature profiles, and turbulent heat fluxes to investigate the spatiotemporal variability of TC-induced OHU and its potential impacts on ocean heat content (OHC) during the period 1985-2018. It is found that category 3-5 TCs dominate the TC-induced OHU, accounting for ~70% of overall amount of TC-induced OHU globally each year. The time series of TC-induced OHU in global and regional oceans exhibit evident interannual-to-interdecadal variability, which is closely related to the TC power dissipation index (PDI). We further decompose PDI into TC intensity, frequency, and duration and find that category 3-5 TC frequency, annually averaged TC intensities, and durations all contribute to the variability of TC-induced OHU except that the averaged TC intensities have no significant relations with the TC-induced OHU in the North Indian Ocean, South Indian Ocean, and Southwest Pacific. In addition, the TC-induced OHU is shown to be responsive to equatorial SSTs rather than tropical SSTs, implying that the TC-induced OHU is modulated by El Niño-Southern Oscillation (ENSO). The TC-induced OHU might have the potential to influence OHC variability, particularly in the equatorial Pacific, where there is significant TC-induced OHU convergence. It has an important implication that TC-induced OHU might have potential effects on ENSO evolution.