Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations
- Resource Type
- Authors
- Brian A. Lanman; Andrew T. Parsons; Stephan G. Zech
- Source
- Accounts of Chemical Research. 55:2892-2903
- Subject
- Proto-Oncogene Proteins p21(ras)
Pyrimidines
Pharmaceutical Preparations
Pyridines
Stereoisomerism
General Medicine
General Chemistry
Piperazines
- Language
- ISSN
- 1520-4898
0001-4842
ConspectusNearly a century after its first description, configurationally stable axial chirality remains a rare feature in marketed drugs. In the development of the KRAS