Examination of mercaptobenzyl sulfonates as catalysts for native chemical ligation: application to the assembly of a glycosylated Glucagon-Like Peptide 1 (GLP-1) analogue
- Resource Type
- Authors
- Ben Cowper; Andrew Hacking; Bhavesh Premdjee; Aileen F. Bongat White; Tsz Mei Sze; Derek Macmillan
- Source
- Chemical Communications. 51:3208-3210
- Subject
- chemistry.chemical_classification
Chemistry
Aryl
Molecular Sequence Data
Metals and Alloys
General Chemistry
Native chemical ligation
Glucagon-like peptide-1
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
Acetic acid
Sulfonate
Glucagon-Like Peptide 1
Sequence Analysis, Protein
Materials Chemistry
Ceramics and Composites
Thiol
Organic chemistry
Amino Acid Sequence
Sulfhydryl Compounds
Solubility
Peptides
- Language
- ISSN
- 1364-548X
1359-7345
3/4-Mercaptobenzyl sulfonates were investigated as aryl thiol catalysts for native chemical ligation (NCL). Whilst catalysing NCL processes at a similar rate to 4-mercaptophenyl acetic acid (MPAA), the increased polarity and solubility of 3-mercaptobenzyl sulfonate in particular may favour its selection as NCL catalyst in many instances.