Distinct inactivated bacterial-based immune modulators vary in their therapeutic efficacies for treating disease based on the organ site of pathology
- Resource Type
- Authors
- Mihai G. Netea; Stephanie Wong; Amanda M. Costa; Mark Bazett; Salim Dhanji; Ho Pan Sham; Shirin Kalyan; Momir Bosiljcic; David W. Mullins; Beryl Luk; Hal Gunn
- Source
- Scientific Reports, 10
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
- Subject
- Pathology
medicine.medical_specialty
Injections, Subcutaneous
Immunology
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
lcsh:Medicine
Disease
Stimulus (physiology)
Biology
Adaptive Immunity
Cancer Vaccines
Article
Mice
Immune system
Immunogenicity, Vaccine
Cell Line, Tumor
Neoplasms
medicine
Animals
Humans
lcsh:Science
Pathogen
Multidisciplinary
Innate immune system
Effector
lcsh:R
Acquired immune system
Phenotype
Immunity, Innate
Disease Models, Animal
Treatment Outcome
Vaccines, Inactivated
Bacterial Vaccines
lcsh:Q
Immunization
Female
Immunotherapy
Immunologic Memory
- Language
- ISSN
- 2045-2322
Contains fulltext : 218672.pdf (Publisher’s version ) (Open Access) Recent developments in understanding how the functional phenotype of the innate immune system is programmed has led to paradigm-shifting views on immunomodulation. These advances have overturned two long-held dogmas: (1) only adaptive immunity confers immunological memory; and, (2) innate immunity lacks specificity. This work describes the observation that innate immune effector cells appear to be differentially recruited to specific pathological sites when mobilized by distinct inactivated bacterial-based stimuli administered subcutaneously. The studies presented suggest that the immune system, upon detecting the first signs of a potential infection by a specific pathogen, tends to direct its resources to the compartment from which that pathogen is most likely originating. The findings from this work puts forth the novel hypothesis that the immunotherapeutic efficacy of a microbial-based stimulus for innate immune mobilization depends on the correct selection of the microbial species used as the stimulant and its relationship to the organ in which the pathology is present.