Effects of changes in arterial pressure on organ perfusion during septic shock
- Resource Type
- Authors
- Katia Donadello; Jean Louis Vincent; Daniel De Backer; Aurélie Thooft; Jacques Creteur; Diamantino Salgado; Fabio Silvio Taccone; Raphael Favory
- Source
- Critical care, 15 (5
- Subject
- Male
Mean arterial pressure
Cardiac output
Shock, Septic -- drug therapy -- physiopathology
Aged
Blood Pressure
Dose-Response Relationship, Drug
Female
Hemodynamics
Humans
Microcirculation
Middle Aged
Mouth Floor
Norepinephrine
Prospective Studies
Shock, Septic
Treatment Outcome
Vasoconstrictor Agents
Critical Care and Intensive Care Medicine
Dose-Response Relationship
medicine
Blood Pressure -- drug effects
Septic shock
business.industry
Septic
Norepinephrine -- pharmacology
Shock
Microcirculation -- drug effects
Sciences bio-médicales et agricoles
medicine.disease
Mouth Floor -- blood supply
Blood pressure
Shock (circulatory)
Anesthesia
medicine.symptom
Drug
Vasoconstrictor Agents -- pharmacology
business
Perfusion
Hemodynamics -- drug effects
- Language
- English
- ISSN
- 1364-8535
Septic shock is characterized by altered tissue perfusion associated with persistent arterial hypotension. Vasopressor therapy is generally required to restore organ perfusion but the optimal mean arterial pressure (MAP) that should be targeted is uncertain. The aim of this study was to assess the effects of increasing MAP using norepinephrine (NE) on hemodynamic and metabolic variables and on microvascular reactivity in patients with septic shock.
Journal Article
SCOPUS: ar.j
info:eu-repo/semantics/published