Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin
- Resource Type
- Authors
- Antonio Brambilla; Dario Mirabile; Marco Zadra; Luigi Carlo Erli; Roberto Grandi
- Source
- Seizure. 7(5):415-416
- Subject
- Adult
Cyclohexanecarboxylic Acids
Gabapentin
gabapentin
Antiepileptic drug
Clinical Neurology
Acetates
Epilepsy
Maintenance therapy
medicine
Humans
acute intermittent porphyria
antiepileptic drugs
Amines
gamma-Aminobutyric Acid
Acute intermittent porphyria
Patient affected
business.industry
General Medicine
medicine.disease
Treatment Outcome
Porphyria
Neurology
Porphyria, Acute Intermittent
Anesthesia
epilepsy
Anticonvulsants
Female
Neurology (clinical)
business
Drug metabolism
medicine.drug
- Language
- ISSN
- 1059-1311
Treatment of seizures in acute intermittent porphyria represents a therapeutic dilemma. Patients needing chronic therapy often experience acute porphyric attacks due to increased hepatic metabolism induced by the antiepileptic drugs themselves. Gabapentin is a new antiepileptic drug not appreciably metabolized by the liver in humans, and it appears to be safe and effective in the maintenance therapy of epilepsy in these patients. We report a patient affected by partial and generalized seizures in the course of acute intermittent porphyria, who was safely and successfully treated with gabapentin.