Impaired Glutamatergic Neurotransmission in Migraine With Aura? Evidence by an Input-Output Curves Transcranial Magnetic Stimulation Study
- Resource Type
- Authors
- Simona Talamanca; Brigida Fierro; Filippo Brighina; Antonio Palermo; Giuseppe Cosentino; Simone Vigneri; Angela Rita Puma
- Source
- Headache: The Journal of Head and Face Pain. 51:726-733
- Subject
- Aura
medicine.medical_treatment
Neurological disorder
medicine.disease
Migraine with aura
Transcranial magnetic stimulation
medicine.anatomical_structure
Neurology
Migraine
Anesthesia
medicine
Ictal
Neurology (clinical)
Levetiracetam
medicine.symptom
Psychology
Motor cortex
medicine.drug
- Language
- ISSN
- 0017-8748
(Headache 2011;51:726-733) Objective.— An imbalance between activity of inhibitory and facilitatory intracortical circuits could play a central role in migraine etiology. We used input–output curves to achieve further information about intracortical excitability of motor cortex in migraine with aura. Methods.— Input–output curves were measured in the right abductor pollicis brevis muscle at rest in 12 patients suffering from migraine with aura and 8 healthy subjects. Stimuli were delivered at intensity ranging from 100% to 160% of resting motor threshold with 10-second inter-stimulus intervals. Seven patients were studied before and during treatment with levetiracetam. Results.— Results showed a greater motor-evoked potential amplitude in response to increasing intensity of stimuli in patients compared to controls (P