Structure-activity relationship, docking analysis and ADME properties of newly designed, potent serotonin 5HT1a receptor ligands
- Resource Type
- Authors
- Jevtić, Ivana I.; Andrić, Deana; Penjišević, Jelena; Šukalović, Vladimir; Dukić-Stefanović, Slađana; Kostić-Rajačić, Slađana
- Source
- Book of abstracts-EFMC-YMCS-Young Medicinal Chemists' Symposium, September 8-9, 2022, Nice, France
EFMC-YMCS Young Medicinal Chemists' Symposium, Nica, France
- Subject
- Serotonin
Serotonin-1A receptor
G-protein
5HT1a
ADME
- Language
- English
Serotonin 5HT1a receptors belongs to a class G-protein coupled receptors and it is widely recognized as one of the targets for treating neurological disorders such depression and schizophrenia. N-arylpiperazine structural motif is present in many compounds with pronounced 5HT1a activity including recently approved aripiprazole for the treatment of the major depressive disorder.