Frontotemporal lobar degeneration and social behaviour: Dissociation between the knowledge of its consequences and its conceptual meaning
- Resource Type
- Authors
- Roland, Zahn; Sophie, Green; Helen, Beaumont; Alistair, Burns; Jorge, Moll; Diana, Caine; Alexander, Gerhard; Paul, Hoffman; Benjamin, Shaw; Jordan, Grafman; Matthew A, Lambon Ralph
- Source
- Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
- Subject
- Male
Impulsivity
Middle Aged
Neuropsychological Tests
Disinhibition
Temporal Lobe
Behavioural Neurology
Knowledge
Brodmann Area 10
Social behaviour
Frontotemporal Dementia
Humans
Female
Frontal lobe
Frontotemporal Lobar Degeneration
Gray Matter
Social Behavior
Aged
- Language
- ISSN
- 1973-8102
Inappropriate social behaviour is an early symptom of frontotemporal lobar degeneration (FTLD) in both behavioural variant frontotemporal dementia (bvFTD) and semantic dementia (SD) subtypes. Knowledge of social behaviour is essential for appropriate social conduct. The superior anterior temporal lobe (ATL) has been identified as one key neural component for the conceptual knowledge of social behaviour, but it is unknown whether this is dissociable from knowledge of the consequences of social behaviour. Here, we used a newly-developed test of knowledge about long-term and short-term consequences of social behaviour to investigate its impairment in patients with FTLD relative to a previously-developed test of social conceptual knowledge. We included 19 healthy elderly control participants and 19 consecutive patients with features of bvFTD or SD and defined dissociations as performance differences between tasks for each patient (Bonferroni-corrected p