Administration of Hydrocotyl bonariensis aqueous leaves extract regulates cardiovascular disease risk factors in galactose model of experimental cataractogenesis
- Resource Type
- Authors
- Adegbesan; O Bukola; O Emmanuel; T Kuburat; Ajani; Adebayo; Salau; L Olusegun; Odufuwa; A Bamidele
- Source
- Scientific Research and Essays. 7
- Subject
- medicine.medical_specialty
Triglyceride
Chemistry
General Engineering
General Physics and Astronomy
Weanling
General Medicine
Fibrinogen
General Biochemistry, Genetics and Molecular Biology
Treatment period
Phytomedicine
chemistry.chemical_compound
Endocrinology
Galactose
Internal medicine
Disease risk
medicine
Platelet
General Agricultural and Biological Sciences
medicine.drug
- Language
- ISSN
- 1992-2248
Reports had indicated that Hydrocotyl bonariensis contains phytochemicals that can be exploited for the development of anticataractogenic agent. In the present study we investigated the effects of administration of the plant’s leaves extract on some cardiovascular disease (CVD) risk factors in galactose model of experimental cataract. Twenty five (25) weanling rats randomly assigned to five groups were used in the study. Aqueous extract of H. bonariensis at 500 and 1000 mgKg-1 were administered to two different groups of the rats placed on galactose diet. Plasma lipid profile, fibrinogen and platelet count were then compared after 4 weeks treatment period between these groups and with the baseline, normal and test control groups. Result of the study indicates that galactose diet elicit significant increase in the plasma cholesterol, triglyceride and artherogenic risk index (AI) whereas simultaneous administration of the extract significantly (p