Aims Mood disorders are common in patients with cardiac implantable electronic devices (CIEDs). The COVID-19 pandemic may have further undermined their emotional well being exacerbating physical symptoms such as palpitations. We investigated the occurrence of anxiety and palpitations in CIEDs patients during the pandemic. In those with remote monitoring (RM) available, we evaluated whether these symptoms were associated with arrhythmic events. Methods and results The generalized anxiety disorder (GAD) 7-items questionnaire and the frequency of palpitations were assessed by telephonic interview. Overall 152 CIEDs patients agreed to be interviewed (119 males, age 69 ± 14 years). The RM was available in 54/152 (36%). Thirty-seven (24%) and 43 (28%) patients had anxiety and palpitations, respectively, and 23 (15%) patients had both. Women were more likely to have symptoms than men (50% vs. 20%; P Conclusions Patients with CIEDs were likely to experience anxiety and palpitations during the COVID-19 outbreak and the RM has been pivotal to ascertain the occurrence of arrhythmic events and device malfunctioning in symptomatic and asymptomatic patients as well.