Bridging β-Cyclodextrin Prevents Self-Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids
- Resource Type
- Authors
- Dmitri Colesnic; Vincent Calvez; Mickaël Ménand; Laurent Bouteiller; Matthieu Sollogoub; Pierre Evenou; Sergii Rudiuk; Anne-Geneviève Marcelin; Adélie Gothland; Gaëlle Pembouong; Julien Rossignol; Renaud Barbeyron; Damien Baigl
- Source
- Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2018, 57 (26), pp.7753-7758. ⟨10.1002/anie.201802550⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2018, 57 (26), pp.7753-7758. ⟨10.1002/anie.201802550⟩
- Subject
- genetic structures
Supramolecular chemistry
Substituent
Transfection
010402 general chemistry
01 natural sciences
Catalysis
Polymerization
Small Molecule Libraries
chemistry.chemical_compound
[CHIM] Chemical Sciences
[CHIM]Chemical Sciences
RNA, Small Interfering
Luciferases
ComputingMilieux_MISCELLANEOUS
chemistry.chemical_classification
Cyclodextrin
010405 organic chemistry
beta-Cyclodextrins
technology, industry, and agriculture
DNA
General Chemistry
General Medicine
Combinatorial chemistry
3. Good health
0104 chemical sciences
Supramolecular polymers
Microscopy, Fluorescence
chemistry
Nucleic acid
lipids (amino acids, peptides, and proteins)
Hydrophobic and Hydrophilic Interactions
Linker
- Language
- ISSN
- 0044-8249
1433-7851
1521-3773
A bridge to assemble: Cyclodextrins bridged with an ammonium linker bearing a hydrophobic substituent can efficiently form supramolecular polymers and avoid the competing self-inclusion and head-to-head processes. Furthermore, the self-assembling cyclodextrin derivative interacts in a highly cooperative manner with DNA, as demonstrated by compaction experiments. It also interacts cooperatively with siRNA and allows its transfection.