Using Clinical and Biochemical Parameters for Safer Discharges in COVID-19: A Comparative Study
- Resource Type
- Authors
- Abubakar Khan; SA Husain; Seshnag Siddavaram; Victoria Lashmar; Leon D’Cruz
- Source
- Journal of Health Care and Research. 2:33-45
- Subject
- 0301 basic medicine
medicine.medical_specialty
Respiratory rate
Coronavirus disease 2019 (COVID-19)
business.industry
030106 microbiology
Case-control study
medicine.disease
Logistic regression
03 medical and health sciences
Pneumonia
0302 clinical medicine
Internal medicine
Combined test
Etiology
Medicine
030212 general & internal medicine
General hospital
business
- Language
The objective of this retrospective case control study was to determine clinical and biochemical parameters associated with a poorer prognostic outcome in both COVID-19 and non-COVID-19 pneumonias and use these to create safe discharge guidelines. This study in a single respiratory ward of a district general hospital compared admission and discharge C- reactive protein (CRP) levels, eosinophil and lymphocyte counts, respiratory rate, oxygen saturations and NEWS2 score from two groups of patients admitted with either confirmed COVID-19 pneumonia (46 patients) or pneumonia of other aetiology (45 patients). Outcome was defined as either ‘good’ or ‘poor’. Combined values of prognostic markers analysed by binary logistic regression followed by ROC analysis showed a final combined AUC value of 0.955 thus yielding a test that had a better prognostic capability in predicting the outcome of patients with COVID-19. This combined test could be used to guide safe discharge of patients with COVID-19.