Introduction/Background The main objective of this retrospective study was to define risk groups to identify patients at risk of recurrence who may benefit from adjuvant treatment. Methodology Patients who had complete staging surgery for endometrial cancer on between 2000 and 2017 in Istanbul University-Cerrahpasa were analyzed. Patients were divided into groups according to grade of the disease and myometrial invasion (MI). Results A total of 895 patients were identified. The presence of lymphovascular space invasion (LVSI) increased the risk of nodal involvement and decreased 5-year DFS, significantly in each group (table 1). Patients with grade 1–2 disease and no LVSI had less than 4% nodal involvement and more than 91% 5-year DFS (Group I and III). However, the presence of LVSI increased the risk of nodal involvement and recurrence significantly in patients with grade 1–2 disease (Group II and IV). Similarly, LVSI increased the risk of nodal involvement and worsen DFS in patients with grade 3 disease (Groups V to VIII). Conclusion Along with grade and MI, LVSI is a significant factor for predicting nodal involvement. Patients having grade 1–2 tumor with Disclosure Nothing to disclose.