Hydrogen is a promising vector for the storage and transportation of the energy generated from renewable sources due to its high energy density (120 MJ/kg), which exceeds that of coal (24 MJ/kg) and petrol (44 MJ/kg) [1]. Hydrogen can be produced by various processes such as reforming of natural gas, coal or biomass gasification and electrolytically. The production of hydrogen via water splitting, using an electrolyser, is considered the "greenest" way, because it does not produce any direct carbon emissions when powered by renewable sources such as wave, wind and solar [2]. Among the different technologies of electrolysers (liquid alkaline, proton exchange membrane, etc.), there has been a recent surge in interest in that one based on anion-exchange membranes (AEMs) [3]. With respect to the state-of-the-art electrolysers that employ conventional acid polymer electrolyte separators (e.g., perfluorinated systems such as Nafion®), electrocatalysis with AEMs is much more promising. In this work, a FAA3-50 anion-exchange membrane (from FuMa-Tech) has been used, after exchange in KOH solution (1 M), as electrolyte/separator in a single cell of 5 cm2 geometrical area. In the first approach, commercial IrO2 and 40% Pt/C catalysts have been used at the anode and cathode, respectively, to evaluate the membrane under the most convenient conditions. The influence of cell temperature, membrane-electrode assembly (MEA) procedure (catalyst-coated membrane or catalyst coated electrode), ionomer content in the electrodes, use of pure water or KOH solution, on electrolyser performance have been analysed. References [1] J.P. Hughes, J. Clipsham, H. Chavushoglu, S.J. Rowley-Neale, C.E. Banks "Polymer electrolyte electrolysis: A review of the activity and stability of nonprecious metal hydrogen evolution reaction and oxygen evolution reaction catalysts", Renewable and Sustainable Energy Reviews 139 (2021) 110709. [2] A. S. Aricò, S. Siracusano, N. Briguglio, V. Baglio, A. Di Blasi, V. Antonucci "Polymer electrolyte membrane water electrolysis: status of technologies and potential applications in combination with renewable power sources", Journal of Applied Electrochemistry 43 (2013) 107-118