Catalyst- and Oxidizing Reagent-Free Electrochemical Benzylic C(sp3)–H Oxidation of Phenol Derivatives
- Resource Type
- Article
- Authors
- Hou, Zhong-Wei; Zhang, Ming-Ming; Yang, Wen-Chao; Wang, Lei
- Source
- The Journal of Organic Chemistry; June 2022, Vol. 87 Issue: 12 p7806-7817, 12p
- Subject
- Language
- ISSN
- 00223263
A site-selective electrochemical approach for the benzylic C(sp3)–H oxidation reaction of phenol derivatives along with hydrogen evolution has been developed. The protocol proceeds in an easily available undivided cell at room temperature under catalyst- and oxidizing reagent-free conditions. The corresponding aryl aldehydes and ketones are obtained in satisfactory yields, and the gram-scale synthesis is easy to be carried out.