A High-Yielding Preparation of β-Ketonitriles
- Resource Type
- Article
- Authors
- Ji, Yaohui; C. Trenkle, William; V. Vowles, James
- Source
- Organic Letters; March 2006, Vol. 8 Issue: 6 p1161-1163, 3p
- Subject
- Language
- ISSN
- 15237060; 15237052
β-Ketonitriles are important precursors for a wide variety of biologically active heterocycles. A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide β-ketonitriles is reported. The procedure is successful with enolizable and nonenolizable esters as well as hindered nitrile anions.